Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia
نویسندگان
چکیده
منابع مشابه
Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia
Schizophrenia etiology is thought to involve an interaction between genetic and environmental factors during postnatal brain development. However, there is a fundamental gap in our understanding of the molecular mechanisms by which environmental factors interact with genetic susceptibility to trigger symptom onset and disease progression. In this review, we summarize the most recent findings im...
متن کاملCortical parvalbumin interneurons and cognitive dysfunction in schizophrenia.
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and postsynaptic abnormalities in PVBCs,...
متن کاملParvalbumin-positive basket interneurons in monkey and rat prefrontal cortex.
Differences in the developmental origin and relative proportions of biochemically distinct classes of cortical neurons have been found between rodents and primates. In addition, species differences in the properties of certain cell types, such as neurogliaform cells, have also been reported. Consequently, in this study we compared the anatomical and physiological properties of parvalbumin (PV)-...
متن کاملNetworks of parvalbumin-positive interneurons in the basolateral amygdala.
The amygdala is a temporal lobe structure that is required for processing emotional information. Polymodal sensory information enters the amygdala at the level of the basolateral amygdala (BLA) and undergoes local processing, after which the behavioral and autonomic responses that accompany emotions are initiated. Two main neuron types are present in the BLA, pyramidal-like principal neurons th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2013
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2013.00116